Pressure Cycling Technology

Barocyclers are products of Pressure Biosciences Inc. The barocyclers NEP 2320 are optimized for productive biopsy tissue analysis.

DIA tool
Mass Spectrometry

We have several MS instruments of different vendors (Thermo Orbitrap HF, Sciex TripleTOF )

DIA tool
DIA Software

We analyze DIA data with a variety of software tools: OpenSWATH 2.4/2.0, DIANN 1.6/1.7, Skyline , EncyclopeDIA, Spectronaut

Cloud Computing

We developed cloud based tool to anlayze proteomic big data. e.g. BatchServer is a web server for batch effects evaluation, visualization, and correction. Check our gitlab: https://github.com/guomics-lab/

DIA Resource
1. T. Xu et al., ProLuCID: An improved SEQUEST-like algorithm with enhanced sensitivity and specificity. J Proteomics 129, 16-24 (2015)
2. Y. Xuan et al., Standardization and harmonization of distributed multi-center proteotype analysis supporting precision medicine studies. Nat Commun 11, 5248 (2020)
3. Z. Yan et al., High-resolution MS/MS metabolomics by data-independent acquisition reveals urinary metabolic alteration in experimental colitis. Metabolomics 15, 70 (2019)
4. X. Yang, Z. Wang, L. Guo, Z. Zhu, Y. Zhang, Proteome-Wide Analysis of N-Glycosylation Stoichiometry Using SWATH Technology. J Proteome Res 16, 3830-3840 (2017)
5. Y. Yang et al., In silico spectral libraries by deep learning facilitate data-independent acquisition proteomics. Nat Commun 11, 146 (2020)
6. Y. Yoshida, S. Kodai, S. Takemura, Y. Minamiyama, E. Niki, Simultaneous measurement of F2-isoprostane, hydroxyoctadecadienoic acid, hydroxyeicosatetraenoic acid, and hydroxycholesterols from physiological samples. Anal Biochem 379, 105-115 (2008)
7. F. Zhang, W. Ge, G. Ruan, X. Cai, T. Guo, Data-Independent Acquisition Mass Spectrometry-Based Proteomics and Software Tools: A Glimpse in 2020. Proteomics, e1900276 (2020)
8. Z. Zheng et al., Risk factors of critical & mortal COVID-19 cases: A systematic literature review and meta-analysis. J Infect 81, e16-e25 (2020)
9. C.-Q. Zhong et al., Systematic Assessment of the Effect of Internal Library in Targeted Analysis of SWATH-MS. Journal of Proteome Research 19, 477-492 (2020)
10. X. Zou et al., Characteristics of Liver Function in Patients With SARS-CoV-2 and Chronic HBV Coinfection. Clin Gastroenterol Hepatol, (2020).